Antitubercular activity of trifluoperazine, a calmodulin antagonist
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چکیده
منابع مشابه
Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion
We investigated the effect of trifluoperazine (TFP), a calmodulin antagonist, on the fusion of chick skeletal myoblasts in culture. TFP was found to inhibit myoblast fusion. This effect occurs at concentrations that have been reported to inhibit Ca2+-calmodulin in vitro, and is reversed upon removal of TFP. In addition, other calmodulin antagonists, including chlorpromazine, N-(6-aminohexyl)-5-...
متن کاملEffects of Trifluoperazine on Calcium Binding by Calmodulin
Microcalorimetric titrations of calmodulin with Ca" and trifluoperazine (TFP) at various molar ratios have been carried out at 25 "C and at pH 7.0. Ca2+ binding to calmodulin produces heat ( A H ) in the presence of TFP, while heat is absorbed in the absence of TFP. The total heat produced by Ca2+ binding to all four sites is increased at increasing TFP-to-calmodulin ratios, attaining a plateau...
متن کاملEffects of trifluoperazine on calcium binding by calmodulin. A microcalorimetric study.
Microcalorimetric titrations of calmodulin with Ca2+ and trifluoperazine (TFP) at various molar ratios have been carried out at 25 degrees C and at pH 7.0. Ca2+ binding to calmodulin produces heat (-delta H) in the presence of TFP, while heat is absorbed in the absence of TFP. The total heat produced by Ca2+ binding to all four sites is increased at increasing TFP-to-calmodulin ratios, attainin...
متن کاملAntitubercular activity of the fungus Gliocladium sp. MR41 strain
Tuberculosis (TB) is leading cause of death worldwide from infectious diseases and its inadequate treatment has led to emergence of resistant strains. The emergence of these strains renders the search for new drugs for the treatment of TB. The aim of this study was the evaluation of the anti-TB activity of the extract from fungus Gliocladium sp. MR41, and bioassay-guided fractionation and ident...
متن کاملAntitubercular activity of the fungus Gliocladium sp. MR41 strain
Tuberculosis (TB) is leading cause of death worldwide from infectious diseases and its inadequate treatment has led to emergence of resistant strains. The emergence of these strains renders the search for new drugs for the treatment of TB. The aim of this study was the evaluation of the anti-TB activity of the extract from fungus Gliocladium sp. MR41, and bioassay-guided fractionation and ident...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1992
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1992.tb05442.x